Regulation of zinc homeostasis by inducible NO synthase-derived NO: Nuclear metallothionein translocation and intranuclear Zn2+ release

Regulation of zinc homeostasis by inducible NO synthase-derived NO: nuclear metallothionein translocation and intranuclear Zn2+ release.

Zn2+ is critical for the functional and structural integrity of cells and contributes to a number of important processes including gene expression. It has been shown that NO exogenously applied via NO donors resulting in nitrosative stress leads to cytoplasmic Zn2+ release from the zinc storing protein metallothionein (MT) and probably other proteins that complex Zn2+ via cysteine thiols. We sh...

NO running on MT: regulation of zinc homeostasis by interaction of nitric oxide with metallothionein.

THE CLASSICAL SIGNALING PATHWAY for nitric oxide (NO) is the binding and subsequent activation of soluble guanylate cyclase. However, the number of pathophysiological pathways mediated by NO has been expanding to include processes that are independent of guanylate cyclase. A number of alternative reaction pathways for NO have been proposed to account for these effects, most notably S-nitrosylat...

Absence of Functional Inducible NO Synthase

Increase of lead-induced release of N-acetyl-p-D-glucosaminidase by NO synthase in perfused kidney of rat

  Urinary N-acetyl-β-D-glucosalninidase (NAG) has been proved to be a useful marker of early renal injury as a result of factors such as lead toxicity. In this study the effect of lead acetate on the kidney and its correlation with the nitric oxide (NO) system was investigated by determining the NAG release in perfused kidney of rat. Lead acetate caused a time- and dose-dependent increase in en...

Inducible NO synthase: role in cellular signalling.

The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent vasodilatory effects, NO was found under certain circumstances to be responsible for the killing of microorganisms and tumour cells by activated macrophages and to act as a novel, unconventional type of ...